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Even in ancient times people are unaware in the existence of living organisms invisible to the eye, causing disease. As a result, the ancient Greek scientist and doctor Hippocrates expressed this assumption in one of his performs. But come to grips with their study of mankind has been in a position only following the Dutch optician van Leeuwenhoek within the XVI century created the initial microscope and saw firsthand the bacteria within a drop of water. Having said that, several inside the class scientist denied the existence of pathogens inside just a few centuries right after the invention of Leeuwenhoek.